PDGF AA as mediator in nicotine-dependent carcinogenesis
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منابع مشابه
TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms.
Transforming growth factor-beta 1 (TGF-beta 1) has been implicated in mediating smooth muscle cell (SMC) growth after vascular injury. Studies examining TGF-beta-induced growth of cultured SMC have identified only modest mitogenic effects which are largely dependent on autocrine production of platelet-derived growth factor-AA (PDGF-AA). Recent studies have suggested, however, that TGF-beta also...
متن کاملPDGF receptor- modulates metanephric mesenchyme chemotaxis induced by PDGF AA
Jill M. Ricono,* Brent Wagner,* Yves Gorin, Mazen Arar, Andrius Kazlauskas, Goutam Ghosh Choudhury, and Hanna E. Abboud Department of Molecular Medicine, Institute of Biotechnology, Departments of Medicine and Pediatrics, University of Texas Health Science Center, and South Texas Veterans Health Care System/Audie L. Murphy Memorial Hospital Division, San Antonio, Texas; and Schepens Eye Institu...
متن کاملBiological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.
BACKGROUND Platelet-derived growth factors (PDGF)-AA and -CC mediate renal fibroblast proliferation and/or renal fibrosis. Whereas PDGF-CC binds to both the PDGF receptors (PDGFRs)-αα- and -αβ, PDGF-AA binds more selectively to the αα-receptor, suggesting potential differences in the biological activities. METHODS We compared signal transduction, gene expression as well as changes in the prot...
متن کاملPDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. It is made up of two polypeptide chains (A and B) combined in three disulfide-linked dimeric forms (AA, AB, and BB). Here, the biosynthesis and proteolytic processing of the two homodimeric forms of PDGF (AA and BB) were studied in CHO cells stably transfected with A-chain (short splice version) or B-chain cDNA....
متن کاملSerial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
UNLABELLED INTRODUCTION Anti-VEGF treatment has proven effective in recurrent ovarian cancer. However, the identification of the patients most likely to respond is still pending. It is well known that the angiogenesis is regulated by several other pro-angiogenic proteins, e.g. the platelet - derived growth factor (PDGF) system and the fibroblast growth factor (FGF) system. These other signal...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1996
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/17.9.1813